Ultimately, it is up to the characters not only to survive, but to discover the truth behind Le MU and themselves as well.
Pluripotent: Embryonic stem cells are able to develop into any type of cell, excepting those of the placenta.
Ever 17 is the tale of seven individuals who come to be trapped within the underwater marine theme park, Le MU, 51 meters below the surface.
During an apparently normal day at the park, an incident occurs, placing almost half of the facility underwater.
While being able to remain undifferentiated, ESCs also have the capacity, when provided with the appropriate signals, to differentiate (presumably via the initial formation of precursor cells) into nearly all mature cell phenotypes.
Due to their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease.
In addition, Le MU is under constant assault by severe water pressure, limiting time to find a means of escape to 119 hours.
Pluripotent stem cells have shown potential in treating a number of varying conditions, including but not limited to: spinal cord injuries, age related macular degeneration, diabetes, neurodegenerative disorders (such as Parkinson's disease), AIDS, etc.
In addition to their potential in regenerative medicine, embryonic stem cells provide an alternative source of tissue/organs which serves as a possible solution to the donor shortage dilemma.
ESC are also described as having a normal karyotype, maintaining high telomerase activity, and exhibiting remarkable long-term proliferative potential.
Embryonic stem cells of the inner cell mass are pluripotent, meaning they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm.